1H, 13C, 15N resonance assignment of human YAP 50–171 fragment
- Autor(en)
- Michael Feichtinger, Tomas Sara, Gerald Platzer, Borja Mateos, Fedir Bokhovchuk, Patrick Chène, Robert Konrat
- Abstrakt
Yes associated protein (YAP) is an intrinsically disordered protein that plays a major role in the Hippo pathway, regulating organ size, cell proliferation, apoptosis, and is associated with cancer development. Therefore, the binding between YAP and TEAD is an interesting target for cancer therapy. The TEAD binding domain of YAP was mapped to protein residues 50–171. To obtain further structural insights into this 12 kDa segment of YAP, we report a backbone and a partial sidechain assignment of recombinant YAP 50–171.
- Organisation(en)
- Institut für Biologische Chemie, Institut für Theater-, Film- und Medienwissenschaft, Department für Strukturbiologie und Computational Biology
- Externe Organisation(en)
- Novartis Institute for Biomedical Research
- Journal
- Biomolecular NMR Assignments
- Band
- 12
- Seiten
- 179-182
- Anzahl der Seiten
- 4
- ISSN
- 1874-2718
- DOI
- https://doi.org/10.1007/s12104-018-9805-8
- Publikationsdatum
- 04-2018
- Peer-reviewed
- Ja
- ÖFOS 2012
- 106041 Strukturbiologie
- Schlagwörter
- ASJC Scopus Sachgebiete
- Structural Biology, Biochemistry
- Sustainable Development Goals
- SDG 3 – Gesundheit und Wohlergehen
- Link zum Portal
- https://ucrisportal.univie.ac.at/de/publications/d6b0df25-27f3-4ff8-bcc0-1db73ea94782